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Diproxen 500mg Tablet 1 Strip
Diproxen is used to alleviate symptoms and inflammation associated with:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Juvenile arthritis
- Tendonitis
- Bursitis
- Acute gout
It is also effective in managing primary dysmenorrhea and various types of pain.
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✅ Description:
Naproxen, a non-selective NSAID, inhibits both COX-1 and COX-2 enzymes, reducing prostaglandin production. While COX-2 is primarily responsible for inflammation, pain, and fever (and hence the therapeutic effects), COX-1 maintains normal functions like protecting the stomach lining. Inhibition of COX-1 is linked to gastrointestinal and renal side effects.
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✔️ Dosage & Administration of Diproxen 500
Naproxen should be taken with water after meals.
Enteric-Coated Tablets – Adults
- Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: 500–1000 mg/day in two divided doses (every 12 hours). Max: 1000 mg/day.
- Acute gout: 750 mg initially, then 250 mg every 8 hours until symptoms resolve.
- Dysmenorrhea: 500 mg initially, then 250 mg every 6–8 hours as needed (up to 5 days).
- Pain/musculoskeletal disorders: 500 mg initially, followed by 250 mg at 6–8 hour intervals.
- Children under 16 years: Not recommended for tablets.
✔️ Drug Interactions
- ACE inhibitors: Reduced antihypertensive effect.
- Antacids/Sucralfate: Delay absorption.
- Aspirin/Warfarin/SSRIs: Increased risk of GI bleeding.
- Diuretics: Decreased natriuretic effect.
- Methotrexate: Heightened toxicity risk.
✔️ Contraindications
- Known hypersensitivity to Naproxen.
- History of asthma or allergic reactions to NSAIDs or aspirin.
- Use in post-CABG surgery pain is contraindicated.
✔️ Side Effects of Diproxen 500
- GI: Nausea, indigestion, abdominal pain, diarrhea.
- CNS: Headache, dizziness, drowsiness.
- Skin: Rash, itching, purpura.
- Cardiovascular: Edema, palpitations.
- Other: Vision and hearing disturbances.
✔️ Use in Pregnancy & Lactation
- May negatively impact fetal development, particularly in the third trimester. Use during the first and third trimesters should be carefully assessed.
- Though small amounts pass into breast milk, some sources advise against use during breastfeeding.
✔️ Precautions & Warnings
- Renal: Monitor kidney function in patients with impaired renal health. Risk of nephropathy, including nephrotic syndrome and interstitial nephritis.
- Hepatic: Cases of jaundice have been reported.
- Cardiovascular/GI Risk: Use with caution in those prone to GI bleeding or CV conditions.
✔️ Storage:
Store below 30°C, protected from moisture and light. Keep out of children’s reach.
Disclaimer:
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
